Postdoctoral Fellow at Tisch Cancer Institute

Postdoctoral Fellow at Tisch Cancer Institute

Tisch Cancer Institute Division of Hematology/Medical Oncology

Job Title: Postdoctoral Fellow
Job Class: TR04
Pay Frequency: Bi-weekly
Exempt Status: Exempt

Job Description

A Postdoctoral positon is currently available within the lab of Dr. Yelena Ginzburg at the Tisch Cancer Institute at the Icahn School of Medicine of Mount Sinai. The lab focuses on iron metabolism and erythropoiesis in health and disease, using mouse models and human samples ex vivo to ask questions about basic biology, physiology, and pathophysiology.

The candidate PhD or MD/PhD in biochemistry, physiology, or molecular biology will have an opportunity to contribute to and shape several ongoing projects within the lab.

The Ginzburg laboratory is a team of scientists and student scientists with deep interest in understanding the crosstalk between erythropoiesis and iron metabolism. We recently also generated preliminary data focused on understanding the crosstalk with bone homeostasis. We are looking for a highly motivated postdoctoral fellow to lead a research project aimed at understanding in detail how iron transport influences erythropoiesis, how the erythron communicates iron requirements to the liver, the main organ involved in hepcidin production, and how the known regulatory nodes influence bone homeostasis.

To accomplish these goals, we aim to utilize standard molecular biology techniques, novel mouse models with mutations in erythropoiesis- and iron-related genes, and state-of-the-art genetic manipulation tools.

Iron transport for erythropoiesis, crosstalk between them, and erythroid regulation of iron metabolism are central tenets in recovery during stress erythropoiesis and are dysregulated in multiple hematological disorders and thus of great interest to the hematology field. Coordination with bone homeostasis is critically important given the proximal physical relationship between bone marrow and bone. The successful completion of this work will provide insight into the pathophysiology of human diseases in which erythropoiesis is disturbed (e.g. β-thalassemia, polycythemia vera, and MDS), extend current knowledge in iron metabolism and bone homeostasis, and add new paradigms for further exploring erythroid regulation of hepcidin in health and disease.

Candidate Profile

We are looking for a scientist with a solid background in biochemistry, physiology, and molecular biology. Skills in microscopy, flow cytometry, ex vivo hematopoietic stem cell proliferation and differentiation, immunoprecipitation, western blot, ELISA, RT-PCR, transfection using plasmid for knockdown and overexpression, and cell sorting techniques as well as mouse husbandry (i.e. breeding and handling)) are advantageous. The candidate should be able to work independently, in a collaborative manner. A track record of publications in peer-reviewed journals is required.

Duties/Responsibilities

  1. Conduct and design experiments under the direction of lab PI.
  2. Report to PI research progress and maintain a current knowledge of literature in relevant fields.
  3. Maintain good records and contact with collaborators.
  4. Nurture collaborative relationships with fellow scientists within the institution, locally, nationally and internationally.
  5. Summarize experimental data timely and assist in drafting publications under the direction of the PI.
  6. Master computer and technical skills necessary for experimental execution as well as data input and analysis.
  7. Performs other related duties as assigned.

Qualifications

  • A Ph.D. in molecular or cellular biology, biochemistry, genetics, or immunology.
  • Previous experience in basic molecular and cellular biology methods including DNA and RNA isolation, siRNA methods, construct engineering, tissue culture and preparation and analysis of samples through flow cytometry.
  • Previous experience with biochemistry techniques including Western blots and immuno-precipitations among others.
  • Expertise in code writing and/or bioinformatics will be weighed as a plus.
  • The candidate is also expected to be self-motivated, creative and capable of contributing productively in a team environment.
  • Excellent communication skills in written and oral English are essential.

Contact information

Yelena Ginzburg, MD
Office: (212) 241-0579
Yelena.ginzburg@mssm.edu

Ginzburg Lab Website
Ginzburg Lab Efforts

posted: October 21, 2020