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Iron Stories

“Iron Genes” and Where (and How) to Find Them

posted: May 27, 2022
V. Nathan Subramaniam Hepatogenomics Research Group, Centre for Genomics and Personalised Health, School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, Australia.   The identification... read more

The Evolution of Metal-Binding Proteins

posted: January 26, 2022
Ioav Cabantchik and Rachel Nechushtai, PhD, DSc“Life is nothing but an electron looking for a place to rest,” a maxim attributed to Albert Szent-Györgyi (Nobel Prize in Physiology and Medicine 1937... read more

#ProductiveProcrastination on Twitter, Anyone?

posted: September 9, 2021
Anand Ruban AgarvasOne fine Sunday drinking coffee with a few friends (brilliant scientists), I casually complained how I often waste time doom-scrolling on Twitter, the social media. What struck me was their answers: one... read more

Iron and Oxygen Homeostasis — Parallels as well as Intersections

posted: August 9, 2021
Samira Lakhal-Littleton, PhDIt is undisputed that there are many intersections between iron and oxygen at the cellular and systems levels. At the cellular level, iron is required for the utilisation of oxygen in oxidative... read more

Iron, Friedreich’s Ataxia and Intermediary Metabolism

posted: March 24, 2021
Kostas Pantopoulos In a paper recently published in Blood (doi: 10.1182/blood.2020006987), Petit et al identify a mechanism promoting cellular iron overload in Friedreich’s ataxia (FRDA), a neurodegenerative... read more

Normal Iron and Hemoglobin Levels Are Needed for Optimizing the Response to COVID-19 Vaccination

posted: February 19, 2021
These Are the EHA RecommendationsIoav Cabantchik and Chaim Hershko. Professors Emeriti of Institute of Like Sciences and Hadassah Faculty of Medicine, The Hebrew University of Jerusalem, IsraelIn an announcement released... read more

Ironing Out Mechanisms of Ferroptosis

posted: February 2, 2021
Karin FinbergAn intriguing, emerging area of iron biology is the process of ferroptosis, an iron-dependent form of cell death driven by oxidative damage to phospholipids. Ferroptosis has been linked to neurogenerative... read more

Reincarnation or Atavism in the Iron Field

posted: November 20, 2019
Ioav CabantchikDID YOU KNOW?“The medieval practice of bloodletting was based on the Moslem medical writers who emphasized revulsion (bleeding from a site located as far from the ailment as possible). This position... read more

To Kiss or Not to Kiss — That Is the Question!

posted: March 19, 2019
“In science novelty emerges only with difficulty, manifested by resistance, against a background provided by expectation.” Thomas S. Kuhn, The Structure of Scientific RevolutionsPrem PonkaI started my research... read more

The An Old Ironic Fact Worth Knowing

posted: July 5, 2018
Ioav CabantchikMany of us use commercial ferric ammonium citrate (FAC) as a soluble source of iron(III) for biological experiments. The commercial product appears often in different colors, primarily brown or dark green or... read more

The Spinach Popeye Iron Decimal Error Story (SPIDES): Why you should always check your references

posted: June 30, 2018
Mike SuttonAbstractTo inform knowledge in research methods and dissemination ethics for the natural and social sciences, this article reinforces the importance of citation to support all assertions of fact. New findings... read more

A Career Forged in Iron

posted: June 18, 2018
Lawrie W. PowellWhen asked to contribute to this “Master’s Series” by Dr. Boyer, I was honored and promptly agreed. However, no sooner had I accepted his offer than I had second thoughts, particularly... read more

The Story of non-transferrin Bound Plasma Iron – NTBI LPI

posted: June 11, 2018
Chaim HershkoMy involvement in iron research started in the laboratories of Clem Finch in 1970 after receiving an NIH International Post Doctoral fellowship. Clem was puzzled at that time by the apparent difference in... read more

Deferiprone – The first approved orally active iron chelator

posted: April 26, 2018
Bob Hider Institute of Pharmaceutical Science King’s College LondonPatients with chronic refractory anemias receiving regular blood transfusions accumulate iron with potential damage to the liver, endocrine system... read more

The Pioneering Role of the Rennes School in Haemochromatosis

posted: April 12, 2018
Pierre Brissot Les Colloques de L’Institut servier Université de Rennes 1, Faculté de Médecine, Inserm-UMR 1241 (Rennes-France)Notes are linked to the references page.INTRODUCTIONWhenever the idea of pioneer... read more

My Iron Story: Wandering in Search of a Scientific Home

posted: April 12, 2018
Clara Camaschella San Raffaele Scientific Institute, Milano, ItalyMy “story” with iron started while preparing my MD thesis on hemoglobinopathies. It was then that I “encountered” iron within the... read more

Ferritins, the senior proteins of iron metabolism

posted: March 17, 2018
Paolo Arosio Università degli Studi di Brescia Department of Molecular and Translational Medicine Brescia, Italy.Why ferritins? Ferritin is the first discovered molecule implicated in iron metabolism (1937), about a... read more